Trulicity
dulaglutide — GLP-1 receptor agonist by Eli Lilly
GLP-1subcutaneous injectionOnce weeklyFDA Approved
Reviewed by Dr. Elena Vance, DOLast reviewed 2 sources cited
FDA-Approved Indications
- Type 2 diabetes mellitus (adjunct to diet and exercise)
- Reduction of major adverse cardiovascular events in adults with type 2 diabetes and established cardiovascular disease or multiple cardiovascular risk factors
Dosing
| Route | subcutaneous injection |
| Frequency | Once weekly |
| Starting Dose | 0.75 mg weekly |
| Maintenance | 1.5 mg weekly |
| Max Dose | 4.5 mg weekly |
| Titration | 0.75 mg x 4 weeks → 1.5 mg. May increase to 3 mg after 4 weeks → 4.5 mg after 4 weeks. |
Side Effects
| Side Effect | Frequency | Severity |
|---|---|---|
| Nausea | 12-21% | 2/5 |
| Diarrhea | 8-13% | 2/5 |
| Vomiting | 6-12% | 3/5 |
| Abdominal pain | 6-9% | 2/5 |
| Decreased appetite | 4-9% | 1/5 |
| Dyspepsia | 4-6% | 1/5 |
| Fatigue | 4-6% | 1/5 |
| Pancreatitis (rare) | <0.5% | 5/5 |
Cost
| List Price | $950-$1,100/month |
| With Insurance | $25-$150/month (varies by plan) |
| Savings Card | $25/month (Lilly savings card, commercially insured) |
Pricing last updated 2026-04-14. Actual costs vary by pharmacy, insurance plan, and location.
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Boxed Warning
Thyroid C-cell tumors: In rodents, dulaglutide causes thyroid C-cell tumors. It is unknown whether dulaglutide causes thyroid C-cell tumors in humans.
Sources
This content is for informational purposes only and is not medical advice. Always consult your healthcare provider before making medication decisions. See our full medical disclaimer.